Patrick Bamford’s penalty miss proved costly as Leeds saw their three-match winning run in the Championship end with a 1-0 defeat at Stoke.
Whites substitute Bamford could have put the Yorkshire side ahead at the bet365 Stadium in the 75th minute but fired over from the spot.
And minutes later at the other end, Wesley’s header clipped the bottom of the crossbar and went in off Leeds captain Pascal Struijk for what proved to be the winner.
Daniel Farke’s side came into the encounter with a 100 per cent record in October, while Alex Neil’s Potters were aiming for successive victories after Saturday’s home triumph against Sunderland.
The Potters had first sight of goal in the opening minute when Andre Vidigal swept in a low shot after meeting Ki-Jana Hoever’s cross but it was straight at Illan Meslier.
Vidigal nearly turned creator in the fifth minute as Ryan Mmaee tested Meslier as Stoke’s bright start continued.
Aside from a misplaced Jordan Thompson pass which they could not capitalise upon, Leeds had very little joy in the final third in the opening stages.
Hoever’s fantastic work on the right led to a dangerous cross for Vidigal but Meslier was once again in the right place, while Mmaee curled over shortly after as Stoke’s onslaught showed no sign of stopping.
Leeds’ first real chance came when Georginio Rutter released Joel Piroe into the box and Mark Travers denied the 26th-minute effort with his legs, before claiming Rutter’s header from the resulting corner.
Stoke’s penalty appeal was waved away by referee Paul Tierney when Mehdi Leris turned and went down under Sam Byram’s challenge on the half-hour.
Mmaee’s endeavour in the box nearly forced an opener in first half stoppage time and Struijk was alert to clear the danger as the ball trickled towards goal.
After the break, Joe Rodon was in the right place to cut out Hoever’s low cross from the right as Stoke continued to threaten, though Jaidon Anthony cut into the box at the other end and curled wide.
Travers was equal to Rutter’s low drive before the hour as Leeds grew in confidence, the Whites striker later firing wide after darting into the box.
Leeds substitute Crysencio Summerville’s first act was to curl a promising effort just wide after 70 minutes.
Bamford won a penalty 15 minutes from time when Ben Pearson brought him down in the box and referee Tierney pointed to the spot, but the striker blasted it over the bar.
And it proved costly as from an 80th minute Hoever corner, Wesley headed against the bar and the ball went in off the unfortunate Struijk for what proved to be the winner.
Stoke’s Alex Neil:
Leeds’ Daniel Farke: